牙周炎和全身炎症作为死亡率的独立和相互作用的风险因素:来自前性队列研究的证据
Christiane Pink1,2, Birte Holtfreter3, Henry Völzke4,5
1Department of Restorative Dentistry, Periodontology, Endodontology and Preventive and Pediatric Dentistry, University Medicine Greifswald, Fleischmannstr. 42, 17475, Greifswald, Germany. christiane.pink@uni-greifswald.de.
BMC medicine
|November 12, 2023
概括
牙周炎和全身炎症显著增加所有原因和心血管疾病 (CVD) 死亡率的风险. 结合起来,它们带来了相当大的过度风险,这表明牙周治疗可以降低心血管疾病死亡率.
科学领域:
- 研究口腔健康 (牙周炎) 和全身健康 (炎症) 与死亡率的交叉关系.
- 专注于基于人口的队列研究中的心血管疾病 (CVD) 和全因死亡率.
背景情况:
- 低度系统性炎症与牙周炎与心血管疾病 (CVD) 结果的联系有关.
- 牙周炎,全身炎症和死亡率之间的独立和相互关联需要进一步澄清.
研究的目的:
- 检查牙周炎和低度系统性炎症与所有原因和心血管疾病死亡率的独立和相互关联.
- 评估牙周炎和全身炎症对死亡风险的相互作用.
主要方法:
- 利用了来自3047名参与者在前性,以人口为基础的波梅兰健康研究 (SHIP-START) 的数据.
- 对参与者进行了13.0±2.4年的跟踪,分析了使用对共变量调整的考克斯比例危险模型的关联.
- 采用了联合模型来分析乘法和加法尺度上的相互作用,计算因相互作用而导致的相对超额风险 (RERI).
主要成果:
- 牙周炎标志物 (例如牙周炎得分,缺失的牙) 和炎症标志物 (白细胞,纤维素,CRP) 与全因死亡率有关.
- 牙周炎标志物与心血管疾病 (CVD) 死亡率有显著的关联.
- 添加性相互作用建模表明,死亡率显著增加:所有原因死亡率为18.9%,心血管疾病死亡率为27.8%,原因是牙周炎和炎症的结合.
结论:
- 牙周炎和全身炎症都与所有原因和心血管疾病死亡率有显著的关联.
- 由于牙周炎和炎症之间的相互作用,存在大量的过度死亡风险.
- 针对牙周炎和全身炎症,可能通过牙周干预措施,可以降低心血管疾病死亡风险.
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