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Updated: Jul 11, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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由内在无序区域进行的分子内部和分子间调节控制PUF蛋白与RNA结合

Chen Qiu1, Zihan Zhang2, Robert N Wine1

  • 1Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.

Nature communications
|November 12, 2023
PubMed
概括

雌-3结合因子-2 (FBF-2) 蛋白质乱的尾部抑制其RNA结合. 伴侣蛋白质LST-1结合释放了这种抑制,增强了FBF-2的RNA亲和力,以调节生殖干细胞.

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