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相关概念视频

Genomics02:02

Genomics

36.4K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Applications of Molecular Taxonomy01:20

Applications of Molecular Taxonomy

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Molecular taxonomy has revolutionized the understanding and classification of bacteria, providing precise insights into their diversity, evolutionary relationships, and ecological roles. By utilizing molecular techniques such as DNA sequencing and fingerprinting, researchers have made significant strides in various fields related to bacterial studies.Resolving Taxonomic AmbiguitiesMolecular taxonomy has been instrumental in distinguishing closely related bacterial species initially thought to...
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DNA Microarrays02:34

DNA Microarrays

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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
17.5K
Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.9K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.9K
RNA-seq03:21

RNA-seq

10.0K
RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...
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Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

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Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
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相关实验视频

Updated: Jul 11, 2025

Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
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Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine

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STOmicsDB:用于空间转录学数据共享,分析和可视化的综合数据库.

Zhicheng Xu1, Weiwen Wang1, Tao Yang1

  • 1China National GeneBank, BGI Research, Shenzhen 518120, China.

Nucleic acids research
|November 12, 2023
PubMed
概括
此摘要是机器生成的。

空间转录学数据库 (STOmicsDB) 为空间转录学数据提供了一个集中资源. 这种全面的数据库促进了跨多个物种的数据共享,可视化和分析,促进了生物洞察力.

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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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Leveraging CyVerse Resources for De Novo Comparative Transcriptomics of Underserved Non-model Organisms
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Comprehensive Workflow for the Genome-wide Identification and Expression Meta-analysis of the ATL E3 Ubiquitin Ligase Gene Family in Grapevine
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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 细胞生物学 细胞生物学

背景情况:

  • 空间转录学使单细胞基因表达分析具有空间上下文.
  • 需要一个统一的平台来管理和访问各种空间转录学数据集.

研究的目的:

  • 引入空间转录学数据库 (STOmicsDB) 作为空间转录学数据的全面资源.
  • 为该领域的研究人员提供数据共享,可视化和分析的便利.

主要方法:

  • 整合了218个手动策划的17个物种的空间转录组数据集.
  • 标注了细胞类型,空间区域和基因;进行了细胞与细胞相互作用分析.
  • 开发了数据存档标准和一个增强数据可重复使用的系统.

主要成果:

  • STOmicsDB提供了一个用户友好的界面,用于可视化数百万个单元格.
  • 该数据库支持针对特定研究需求的定制子数据库.
  • 便利数据存档,共享,可视化和分析空间转录学数据.

结论:

  • STOmicsDB 作为一个有价值的,可访问的空间转录学研究中心.
  • 该数据库促进了数据的互操作性,并推动了生物发现.
  • 能够有效地探索和分析复杂的空间基因表达模式.