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Updated: Jul 11, 2025

Determination of Protein-ligand Interactions Using Differential Scanning Fluorimetry
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用非平衡模拟来解码序列特异性蛋白质-DNA复合体的解离.

Thor van Heesch1, Peter G Bolhuis1, Jocelyne Vreede1

  • 1Van 't Hoff Institute for Molecular Sciences, University of Amsterdam, Netherlands.

Nucleic acids research
|November 12, 2023
PubMed
概括

这项研究引入了一种快速的分子模拟方法来预测蛋白质-DNA结合. 该方法准确量化了序列特异性,并提供了对分子相互作用的机制性见解.

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Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
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