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相关概念视频

Genomics02:02

Genomics

36.4K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
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Modern Molecular Taxonomy01:29

Modern Molecular Taxonomy

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Advancements in molecular biology have revolutionized the identification and characterization of bacteria, with multiple methods leveraging DNA sequencing for enhanced precision. As sequencing technologies improve and costs decline, these approaches are increasingly used in clinical, environmental, and evolutionary studies.Multilocus Sequence Typing (MLST) examines several housekeeping genes, essential chromosomal genes encoding cellular functions, to distinguish strains. Approximately...
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Updated: Jul 11, 2025

An Integrated Approach for Microprotein Identification and Sequence Analysis
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An Integrated Approach for Microprotein Identification and Sequence Analysis

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该UCSC基因组浏览器数据库:2024年更新更新

Brian J Raney1, Galt P Barber1, Anna Benet-Pagès2,3

  • 1Genomics Institute, University of California Santa Cruz, Santa Cruz, CA 95064, USA.

Nucleic acids research
|November 12, 2023
PubMed
概括
此摘要是机器生成的。

该UCSC基因组浏览器增强了基因组数据的访问,新的人类泛基因组和病毒基因组信息. 这些更新扩大了它对全球研究人员的实用性.

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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
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科学领域:

  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学

背景情况:

  • 该UCSC基因组浏览器是一个广泛使用的网络工具,用于基因组可视化和分析.
  • 它提供了对众多基因组组合的注释数据的访问.

研究的目的:

  • 报告UCSC基因组浏览器的最新更新和新功能.
  • 突出扩展数据供应和改进的基因组表示.

主要方法:

  • 整合了来自人类泛基因组参考联盟的新数据.
  • 包括病毒基因组,包括SARS-CoV-2.
  • 将GenArk基因组系统扩展为1200个新基因组.
  • 增加了9个新的用户贡献的轨道枢纽.
  • 释放29个新的人类基因组轨迹和11个新的小鼠基因组轨迹.

主要成果:

  • 通过新基因组的添加增加了基因组表示的多样性.
  • 通过公共轨道枢纽增强对用户生成数据的支持.
  • 更广泛,更深入的基因组知识与全球用户群共享.
  • 对人类泛基因组和病毒基因组的扩展数据.

结论:

  • 该UCSC基因组浏览器继续发展为基因组研究的综合资源.
  • 最近的更新显著提高了可用的基因组数据的广度和深度.
  • 这些改进支持越来越多的全球基因组分析用户社区.