RefMetaPlant:五大类植物的参考代谢基因组数据库
Han Shi1,2, Xueting Wu1, Yan Zhu1
1Key Laboratory of Synthetic Biology, Key Laboratory of Plant Design, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Nucleic acids research
|November 12, 2023
概括
研究人员为数百万种植物代谢物创建了一个植物参考代谢组数据库 (RefMetaPlant). 该资源有助于发现和研究植物化学物质,推进植物科学和代谢学研究.
科学领域:
- 代谢学 代谢学 代谢学
- 植物科学 植物科学
- 生物信息学是一种生物信息学.
背景情况:
- 植物表现出巨大的化学多样性,数以百万计的代谢物对生物功能至关重要.
- 有限的参考代谢组和光谱库阻碍了植物化学发现和功能研究.
研究的目的:
- 为植物构建一个全面的参考代谢组.
- 开发用于植物代谢组分析和代谢物识别的综合工具.
主要方法:
- 使用先进的LC-MS平台从150多种植物中生成非定向质谱数据.
- 开发了一个计算协议,用于为153个物种构建参考代谢组.
- 集成的光谱库和开发的查询/分析工具.
主要成果:
- 建立了一个"植物参考代谢数据库" (RefMetaPlant).
- 包括参考代谢组,标准化合物光谱库以及"LC-MS/MS查询"和"RefMetaBlast"等工具.
- 为基因组规模的代谢物分析和识别提供了一个平台.
结论:
- RefMetaPlant作为一种与植物代谢学参考基因组类似的关键资源.
- 促进知识/数据共享和在植物代谢学研究中的合作.
- 数据库和工具是科学界可以免费使用的.
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