EVLncRNAs 3.0:由低通量实验验验证的手动策划的功能性长非编码RNA的最新综合数据库.
Bailing Zhou1, Baohua Ji1,2, Congcong Shen1
1Shandong Provincial Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou 253023, China.
Nucleic acids research
|November 12, 2023
概括
现在EVLncRNAs数据库包括超过25,000个出版物,显著扩大了其实验验证的功能性长非编码RNA (lncRNAs) 和疾病研究相关数据的集合.
科学领域:
- 分子生物学分子生物学
- 基因组学就是基因组学.
- 生物信息学是一种生物信息学.
背景情况:
- 长非编码RNA (lncRNAs) 在生物过程和疾病中起着关键作用.
- 对lncRNAs的功能性表征是必不可少的,但仍然具有挑战性.
- EVLncRNAs数据库为实验验证的功能 lncRNAs 提供了一个精心策划的资源.
研究的目的:
- 以最近的发现更新和扩展EVLncRNAs数据库.
- 用新的数据类型和改进的可用性来增强数据库.
- 为 lncRNA 研究提供一个全面的资源.
主要方法:
- 从2020年5月到2023年5月,对大约25,000个出版物的详尽的手动策划.
- 纳入新的数据类别,包括功能分类,相互作用,结构和与COVID-19相关的lncRNAs.
- 改进网络界面,以增强浏览,可视化和搜索功能.
主要成果:
- 功能性 lncRNAs (154%) 和相关疾病 (160%) 的大幅增加.
- 在 lncRNA-疾病关联 (186%),相互作用 (235%) 和结构 (138%) 的显著增长.
- 循环RNAs (234%),耐药 lncRNAs (235%) 和外体 lncRNAs (4724%) 的显著扩张.
结论:
- EVLncRNAs 3.0 是对实验验证的功能 lncRNAs 最广泛的策划资源.
- 更新的数据库有助于探索新的 lncRNA 功能及其在疾病中的作用.
- 该资源免费提供,对科学界来说将是无价的.
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