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Updated: Jul 11, 2025

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
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在表观遗传序列背景下,由2-酸产生的庞大的阿里胺-dG附的形状依赖性损伤绕道

Alicia M Crisalli1, Yi-Tzai Chen1, Ang Cai1

  • 1Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, RI 02881, USA.

Nucleic acids research
|November 12, 2023
PubMed
概括

像5-甲基细胞素 (5mC) 这样的表观遗传变化会影响细胞如何绕过庞大的DNA损伤,影响病变修复和潜在的癌症风险. 这项研究揭示了5mC对DNA adduct bypass的序列特异性影响.

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