DGIdb 5.0:为精准医学和药物发现平台重建药物基因相互作用数据库
Matthew Cannon1, James Stevenson1, Kathryn Stahl1
1Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA.
Nucleic acids research
|November 12, 2023
概括
更新的药物基因相互作用数据库 (DGIdb) 5.0通过新的架构,GraphQL API和扩展数据源来增强药物发现管道,以提高数据的可访问性和可重复使用性.
科学领域:
- 生物信息学是一种生物信息学.
- 药物基因组学 药物基因组学
- 计算生物学 计算生物学
背景情况:
- 药物基因相互作用数据库 (DGIdb) 是汇总药物基因相互作用的重要资源.
- 之前的版本为研究人员和临床医生促进了假设生成.
研究的目的:
- 介绍DGIdb 5.0,详细介绍其架构和功能增强.
- 改善整合到临床和药物发现工作流程中.
- 增强数据的可访问性,互操作性和可重复使用性.
主要方法:
- 将服务重新构建成单独的客户端和服务器应用程序.
- 使用ReactJS开发了一个新的Web界面,具有动态可视化.
- 实现了一个 GraphQL API,用于可定制的数据查询.
- 整合了六个新的数据源 (ChemIDplus,HemOnc,NCIt,Drugs@FDA,HGNC,RxNorm) 并更新了现有的数据源.
- 使用模块化正常化器增强药物和基因分组方法.
主要成果:
- 通过Web接口和API实现一致的数据访问.
- 通过 GraphQL API 启用灵活且可定制的数据检索.
- 扩展了数据库,增加了新的药物基因相互作用记录和注释.
- 在 DGIdb.com 中改进了 FAIR 数据原则 (可查找性,可访问性,互操作性,可重复使用性).
- 治疗性监管批准状态的增强注释.
结论:
- DGIdb 5.0为药物发现和临床应用提供了一个强大的平台.
- 架构和数据的增强显著提高了数据的实用性和集成.
- 更新后的资源支持用于药物基因相互作用的高级查询和数据分析.
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