囊性纤维化患者在高效调节器治疗中的鼻科护理利用率下降
Ethan J Han1, Daniel M Beswick1, Patricia H Eshaghian2
1Department of Head and Neck Surgery, University of California, Los Angeles, CA, USA.
The Annals of otology, rhinology, and laryngology
|November 13, 2023
概括
在患有囊性纤维化 (PwCF) 的人群中,elexacaftor/tezacaftor/ivacaftor (ETI) 治疗显著减少了鼻科医疗保健访问和鼻腔培养. 这项研究表明ETI.
科学领域:
- 医学研究 医学研究
- 肺部病理学 肺部病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 慢性鼻炎 (CRS) 在患有囊性纤维化 (PwCF) 的人群中很常见.
- CRS管理增加了肺部疾病和医疗保健资源使用的负担.
- 埃尔克萨卡夫托/特萨卡夫托/伊瓦卡夫托 (ETI) 是一种调节剂疗法,可以改善PwCF中的CRS,但其对医疗保健利用的影响尚未得到充分研究.
研究的目的:
- 为了比较PwCF在开始ETI治疗之前和之后的鼻科医疗利用率和程序.
- 评估ETI对PwCF中CRS相关的医疗保健资源消费的影响.
主要方法:
- 对成年PwCF进行了一项单中心,回顾性队列研究.
- 收集了有关人口统计,临床特征和CF治疗的数据.
- 在12个月前和12个月后的ETI启动后,医疗保健利用情况进行了比较.
主要成果:
- 在接受ETI和鼻科护理 (ETI-ENT队列) 的PwCF中,鼻科诊所访问和鼻腔培养频率显著下降.
- 在进行的内镜鼻手术数量上没有观察到显著变化.
- 回归分析没有揭示除ETI外,其他影响利用变化的因素.
结论:
- 在PwCF中,ETI治疗与鼻科医疗利用方面的减少有关.
- 需要进一步的研究,以了解PwCF对ETI的长期鼻科需求.
- 建议进行更大的队列研究来验证这些发现.
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