皮托斯特雷普托科克斯 (Peptostreptococcus anaerobius) 是结直肠癌的一个潜在的诊断生物标志物
Yuchao Zhang1, Kaihu Fan2, Linping Li3
1Department of Gastrointestinal Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Zhangyuchao761023@163.com.
Cellular and molecular biology (Noisy-le-Grand, France)
|November 13, 2023
概括
佩托斯特雷普托科克斯 (Peptostreptococcus anaerobius) (P.a) 在结直肠癌 (CRC) 组织中更为普遍. 在CRC患者中增加P.a的丰度与生存率较差相关,可以预测预后.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
背景情况:
- 佩托斯特雷普托古克 (Peptostreptococcus anaerobius) (P.a) 在结直肠癌 (CRC) 患者中越来越多地被发现.
- P.a具有侵入结直肠组织的能力,这表明它可能在结直肠癌的发展中发挥作用.
研究的目的:
- 调查P.a在结直肠癌 (CRC) 的临床意义.
- 为了确定P.a丰度和CRC患者预后之间的相关性.
主要方法:
- 滴滴数字PCR被用于量化粘膜组织中P.a的绝对拷贝数.
- 从109名CRC病例和65名健康对照人群中采集了样本.
主要成果:
- 在79.8%的CRC组织和55.4%的健康组织中检测到P.a.
- 与健康组织相比,CRC组织中的平均P.a拷贝数 (2.3拷贝/ng DNA) 与健康组织 (0.32拷贝/ng DNA) 相比显著更高.
- P.a的丰度与CRC患者的存活率,年龄,TNM阶段和SQLE水平相关.
结论:
- 结直肠粘膜中的P.a丰富性是CRC的潜在生物标志物.
- 监测P.a水平可能有助于预测结直肠癌的预后.
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