淋巴细胞相关比率,全身免疫炎症和全身炎症反应指数在酒精使用障碍中的使用
Burcu Kok Kendirlioglu1, Hidayet Ece Arat Celik1, Ayse Ece Buyuksandalyaci Tunc1
1Medicine Faculty Department of Psychiarty, Maltepe University, Istanbul, Turkey.
Journal of immunoassay & immunochemistry
|November 13, 2023
概括
酒精使用障碍 (AUD) 与炎症有关. 与健康对照组相比,关键的免疫标志物,如中性粒细胞与淋巴细胞比率 (NLR) 和全身炎症反应指数 (SIRI),在AUD患者中显著高于健康对照组.
科学领域:
- 医学研究 医学研究
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 包括酒精使用障碍 (AUD) 在内的成障碍越来越多地被认为与全身和中枢神经系统炎症有关.
- 虽然在AUD中已经探索了淋巴细胞相关的参数,但系统性免疫炎症指数 (SII) 和系统性炎症反应指数 (SIRI) 的实用性仍未得到充分研究.
研究的目的:
- 调查和比较AUD和健康对照 (HC) 个体之间的淋巴细胞相关比率,SII和SIRI水平.
- 在AUD患者中探索这些炎症标记物和肝酶比率之间的潜在相关性.
主要方法:
- 采用了回顾性,横截面的研究设计.
- 涉及72名被诊断患有AUD的患者和184名健康个体.
- 组间中性粒细胞与淋巴细胞的比率 (NLR),单细胞与淋巴细胞的比率 (MLR),血小板与淋巴细胞的比率 (PLR),SII和SIRI的比较.
主要成果:
- 与HC组相比,AUD组的NLR,MLR和SIRI水平显著升高 (所有人p<0.001).
- 在AUD队列中观察到NLR和AST/ALT比率之间存在显著的正相关性 (p = 0.022).
结论:
- 这些发现支持将AUD归类为慢性炎症性精神疾病.
- 在AUD患者中,与肝酶一起评估炎症标志物可能会为酒精诱导的肝损伤提供见解.
- 这些标记物有可能在未来用于评估AUD的治疗反应和疾病严重程度.
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