相关实验视频

Updated: Jul 11, 2025

Expression and Purification of Virus-like Particles for Vaccination

Expression and Purification of Virus-like Particles for Vaccination

Published on: June 2, 2016

发现和开发COVID-19疫苗从实验室到诊所

Venkatesan Saravanan¹, Bharath Kumar Chagaleti¹, Pavithra Lakshmi Narayanan¹

¹Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRM Institute of Science and Technology, Chengalpattu District, India.

Chemical biology & drug design

|November 13, 2023

概括

由于病毒突变,开发有效的SARS-CoV-2疫苗具有挑战性. 持续监测和先进的计算方法对于成功开发针对COVID-19的疫苗至关重要.

科学领域:

病毒学病毒学
免疫学免疫学免疫学
公共卫生公共卫生

背景情况:

严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 导致了COVID-19大流行,这是一个重大的全球卫生危机.
病毒发生了突变,特别是在非结构性蛋白 (NSP) 和尖端蛋白中,使疫苗开发复杂化.
2014年埃博拉病毒病 (EVD) 爆发突显了新兴传染病的影响.

研究的目的:

审查开发SARS-CoV-2疫苗的挑战.
讨论持续基因组和突变监测的重要性.
探索即将到来的疫苗开发策略,以应对当前和未来的流行病.

主要方法:

审查目前的疫苗开发格局,包括临床和临床前阶段.
分析病毒突变对疫苗疗效的影响.
强调计算方法在彻底改变疫苗设计中的作用.

主要成果:

有相当多的疫苗 (169种临床,198种临床前) 正在开发中.
蛋白质亚单元疫苗是最常见的类型.
病毒突变是疫苗疗效的主要挑战.

结论:

持续监测SARS-CoV-2基因组动态和尖端蛋白突变是必不可少的.
应对长期免疫力,安全性,有效性,稳定性,分布和成本等挑战至关重要.
计算方法为未来的疫苗开发策略提供了一个有希望的方法.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.冠状病毒冠状病毒的新冠病毒.反向接种疫苗的方法疫苗疫苗疫苗疫苗

更多相关视频

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Production of a SARS-CoV-2 Virus-Like-Particle System to Investigate Viral Life Cycles In Vitro

Published on: June 6, 2025

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

相关概念视频

Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

History of Microbiology

History of Microbiology

Microbiology, a scientific field dedicated to the study of microorganisms, has undergone profound development since its inception in the 17th century. Its history is marked by key discoveries and technological advancements that have shaped our understanding of life at the microscopic level and transformed medicine, agriculture, and industry.Early Foundations of MicrobiologyThe early foundations of microbiology were built on groundbreaking observations and the development of pioneering...