在免疫受损患者中通过肺部活检诊断出肺部密码球菌病:一个病例报告
Hongxia Jia1, Hongping Liu1, Meng Tu1
1Department of Pulmonary and Critical Care Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Frontiers in cellular and infection microbiology
|November 13, 2023
概括
这项研究报告了一种罕见的单独的多发性密码球菌病例,仅表现为多发性溢出. 通过肺部活检证实了诊断,导致有效的抗真菌治疗和恢复.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 菌类学 菌类学是指菌类学.
背景情况:
- 胸腺瘤和骨髓灰质炎是自身免疫性疾病,通常通过免疫抑制疗法进行治疗.
- 长期使用葡萄糖皮质类药物和塔克罗利斯可以增加机会性感染的风险.
- 不知来源的复发性肺流需要彻底调查,特别是在免疫受损的个体.
研究的目的:
- 报告一种极为罕见的单独的多叶性密码球菌病例.
- 为了突出表溢出作为感染的唯一表现.
- 强调在复杂病例中胸腔活检的诊断效用.
主要方法:
- 进行了肺部活检组织的病理检查.
- 利用形态分析来识别真菌元素.
- 在病原体鉴定中使用元基因组下一代测序 (mNGS).
主要成果:
- 活检揭示了许多类似酵母菌的生物体,与Cryptococcus neoformans一致.
- mNGS证实了Cryptococcus neoformans具有高物种特异性读数 (SSRN) 的情况.
- 用AMPHOTERICIN B和FLUCONAZOLE进行的抗真菌治疗成功地解决了多流液.
结论:
- 单独的多发性密码球菌病呈现为简单的多发性溢液是非常罕见的.
- 在免疫功能低下的患者中,需要高度警密码球菌病,这些患者有反复复发的多发性液.
- 胸腔活检是推的诊断工具,用于在怀疑加密菌病时确认.
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