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短疗程与长疗程抗菌疗法在成年人与导管相关的败血栓瘤:一个倾向权重的回顾性研究
Marine Stoldick1, Margot Vannier2, Mikael Verdalle-Cazes3
1Department of Infectious Diseases, Centre hospitalier universitaire Rouen, Rouen, France.
Open forum infectious diseases
|November 13, 2023
概括
长达21天的抗菌疗法 (AT) 疗程似乎是安全有效的,用于治疗与导管相关的败血深静脉血栓症 (DVT). 这种持续时间可能足够,减少了许多患者长期治疗的需要.
科学领域:
- 传染性疾病 传染性疾病
- 血管医学 血管医学
- 临床治疗学 临床治疗学
背景情况:
- 与导管相关的败血深静脉血栓症 (DVT) 带来了治疗挑战.
- 对于这种情况,抗微生物治疗 (AT) 的最佳持续时间仍未确定.
研究的目的:
- 为了比较短期 (≤21天) 与长期 (≥21天) 的AT对与导管相关的败血性DVT的结果.
- 评估不同AT持续时间的安全性和有效性.
主要方法:
- 在172名成年患者 (2015-2020年) 的单心回顾性研究中.
- 短路与长路AT的比较.
- 倾向性评分加权分析,以控制混因素.
主要成果:
- 短期和长期AT组之间30天死亡率或复发性血液感染没有显著差异.
- 在90天死亡率或复发率上没有观察到显著差异.
- 权重危险比率表明,在较短的AT持续时间下,风险没有增加.
结论:
- 一个21天的AT课程可能是一个安全和有效的选择,用于导管相关的败血性DVT.
- 需要进一步的随机对照试验来确认最佳的AT持续时间.
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