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早期三阴性乳腺癌的基于capecitabine的化疗:一个元分析

Jie Bai¹, Xufeng Yao^1,2, Yinghong Pu¹

¹Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Frontiers in oncology

|November 13, 2023

概括

辅助性capecitabine改善了早期三阴性乳腺癌 (TNBC) 的存活率. 这一元分析证实,尽管副作用增加,但无病生存期 (DFS) 和整体生存期 (OS) 的好处是如此.

科学领域:

在瘤学瘤学.
药理学研究药理学研究
临床试验分析临床试验分析

背景情况:

辅助性capecitabine在早期三阴性乳腺癌 (TNBC) 的作用需要澄清.
目前关于capecitabine在这种患者群体中的疗效和安全性的数据有限.
需要进行全面的元分析来评估基于capecitabine的疗法,以改善早期TNBC的生存结果.

结论:

辅助性capecitabine化疗为TNBC早期阶段的患者提供了卓越的DFS和OS益处.
对DFS的积极影响特别在特定的亚组中被注意到,包括淋巴结阴性患者和接受较长时间治疗capecitabine的患者.
虽然有效,但由于特定不良事件的风险增加,使用capecitabine需要仔细监测.

关键词:

不良事件不良事件不良事件卡佩西塔宾 (capecitabine) 是一种药物.化疗化疗是一种化学疗法.幸存率幸存率生存率三重阴性乳腺癌是什么

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