那不勒斯预后得分作为成人喘患者的新预后预测指标:基于人口的研究
Ning Zhu1, Shanhong Lin2, Hang Yu1
1Department of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Ningbo, The First Affiliated Hospital of Ningbo University, Ningbo, China.
The World Allergy Organization journal
|November 13, 2023
概括
那不勒斯预后得分 (NPS) 有效预测成人喘患者的死亡率. 较高的NPS得分与所有原因,心血管,癌症和呼吸道死亡率的风险增加有关.
科学领域:
- 肺部病理学 肺部病理学
- 内部医学 内部医学
- 生物统计学 生物统计学
背景情况:
- 喘在全球范围内影响着数百万人,患病率和死亡率很高.
- 预后得分对于分层患者风险和指导治疗至关重要.
- 在喘中,那不勒斯预后得分 (NPS) 的预后价值仍未得到充分研究.
研究的目的:
- 为了评估在患有喘的成年患者中那不勒斯预后得分 (NPS) 的预后价值.
- 评估NPS和喘患病率之间的关联.
- 确定NPS对喘患者全因和因特定死亡率的预测意义.
主要方法:
- 从国家健康和营养检查调查 (NHANES) (1999-2018) 中对44,601名参与者的分析.
- 基于血清白蛋白,总胆固醇,中性粒细胞与淋巴细胞比率 (NLR) 和淋巴细胞与单细胞比率 (LMR) 的NPS计算.
- 使用后勤回归,卡普兰-梅尔分析,考克斯回归和随机生存森林 (RSF) 进行统计分析.
主要成果:
- 较高的NPS (2组) 与喘患病率的增加有关 (OR = 1.40).
- 喘患者在最高的NPS组 (组2) 显示显著增加所有原因 (HR = 2.42),心血管 (HR = 2.68),癌症 (HR = 2.10) 和呼吸道死亡率 (HR = 3.00) 的风险.
- 在RSF模型中,与NPS的各个组成部分相比,NPS是所有原因死亡率的优越预测因素.
结论:
- 那不勒斯预后得分 (NPS) 是成人喘患者的宝贵预后工具.
- 在患有喘的个体中,NPS可以有效地分层死亡风险.
- 这一分数有助于识别高风险的喘患者,他们可能会从更密切的监测和量身定制的干预中受益.
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