相关实验视频

Updated: Jul 28, 2026

Enhancing Tumor Content through Tumor Macrodissection

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

系统性免疫炎症指数对扩散型大B细胞淋巴瘤患者的预后和临床病理影响:元分析

Zaijing Fan¹, Lihong Shou²

¹Clinical Laboratory, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, The Fifth School of Clinical Medicine Zhejiang Chinese Medical University, Huzhou, Zhejiang, China.

Therapeutic advances in hematology

|November 13, 2023

概括

系统性免疫炎症指数 (SII) 是扩散型大B细胞淋巴瘤 (DLBCL) 的显著预后标志物. 较高的SII水平预测DLBCL患者的整体存活率和无进展存活率较差.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
血液学血液学血液学

背景情况:

系统性免疫炎症指数 (SII) 是一个新兴的预后标志物.
它在扩散性大B细胞淋巴瘤 (DLBCL) 的预后价值需要全面评估.

研究的目的:

进行元分析,评估SII与DLBCL患者的预后之间的关联.
评估SII与DLBCL临床病理特征的相关性.

主要方法:

在PubMed,科学网,Embase和Cochrane图书馆数据库中进行系统的文献搜索.
五项研究 (592例) 的元分析,使用危险比率 (HRs) 和赔率比率 (ORs).
评估整体生存 (OS),无进展生存 (PFS) 和临床病理特征.

主要成果:

在DLBCL中,较高的SII显著预测了较差的OS (HR=3.87) 和PFS (HR=2.38).
与B症状相关的SII增加,晚期 (III-IV),高风险IPI,以及中性粒细胞与淋巴细胞和血小板与淋巴细胞的比率升高.
在SII和性别,年龄,LDH,ECOG状态或组织学之间没有发现显著的关联.

结论:

升高的SII是DLBCL中劣质OS和PFS的戏剧性预测因素.
在DLBCL中,SII与关键的临床病理特征显著相关,这些特征表明疾病进展.

关键词:

DLBCL DLBCL 是一个字母.基于证据的医学是基于证据的医学.这是一个元分析.幸存率幸存率生存率系统性免疫炎症指数

更多相关视频

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Author Spotlight: Multiplex Immunofluorescence Combined with Spatial Image Analysis for the Clinical and Biological Assessment of the Tumor Microenvironment

Published on: June 2, 2023

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Author Spotlight: Investigating Immune Cell Dynamics in the Tumor Microenvironment — Challenges and Innovations in Cancer Prognosis

Published on: April 12, 2024

相关概念视频

Chronic Inflammation: Introduction

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...