心房动与中风和痴呆症的关联,考虑到左心房功能和大小
Michael J Zhang1,2, Yuekai Ji3, Wendy Wang3
1Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota.
JACC. Advances
|November 13, 2023
概括
心房动 (AF) 与中风和痴呆有关,但这种风险可能是由心房肌病症解释的. 对左心房功能和大小进行调整,消除了AF与这些疾病之间的显著关联.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 老年病的医生 老年病的医生
背景情况:
- 心房动 (AF) 是已知的缺血性中风 (IS) 和痴呆的风险因素.
- 心房肌病 (左心房功能/大小的改变) 在混这些关联中的作用尚不清楚.
研究的目的:
- 调查流行和发生的AF与IS和痴呆症之间的关联.
- 为了确定左心房 (LA) 功能和大小是否调解或混这些风险.
主要方法:
- 对ARIC研究队列中LA功能和大小的心声学数据的分析.
- 时间变化的考克斯回归被用来分析AF,IS和痴呆症之间的关联,平均随访时间为7.1年.
主要成果:
- 最初,AF与IS和痴呆症的风险增加有显著的关联.
- 经过对LA储菌株,LA收缩菌株,LA排空分数和LA最小体积指数进行调整后,这些关联被减弱了,不再具有统计意义.
结论:
- 观察到的AF,IS和痴呆症之间的关联在考虑心房肌病的措施后,在统计学上并不显著.
- 这项研究表明,心房肌病可能会混这种关系,挑战AF作为IS和痴呆症的独立风险因素的作用.
相关概念视频
Aortic Regurgitation II: Clinical Features and Diagnostic Tests
22
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
22
Dementia
120
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
120
Mitral Stenosis I: Introduction
15
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
15
Mitral Stenosis II: Clinical features and Diagnostic Tests
22
Mitral stenosis is a heart condition in which the mitral valve, which allows blood to flow from the left atrium to the left ventricle, becomes narrowed or stenotic. This narrowing hinders blood flow and leads to clinical symptoms requiring specific medical evaluations and management strategies. The following overview outlines the clinical symptoms, assessments, diagnostic findings, prevention methods, and treatments for mitral stenosis.Clinical ManifestationsDyspnea (shortness of breath): This...
22


