图拉汉塔病毒的植物地理分析强调了它在中欧的单一引入
Valentina Cirkovic1, Simon Dellicour2,3, Gorana Stamenkovic4
1Faculty of Medicine, University of Belgrade, Dr Subotica 8, Belgrade 11000, Serbia.
Virus evolution
|November 13, 2023
概括
图拉脊髓炎病毒 (TULV) 可能起源于黑海地区,并通过单一引入事件传播到欧洲. 这项研究追踪了TULV血统在欧亚大陆的分散历史.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 人类遗传学 是一个学科.
背景情况:
- 脊髓炎病毒是由动物传播的动物性病原体,图拉脊髓炎病毒 (TULV) 对人类的致病性不清楚.
- 对汉塔病毒迁移的植物地理研究是有限的,特别是对于特定的物种,如TULV.
研究的目的:
- 为了重建图拉orthohantavirus (TULV) 血统在欧亚大陆的传播历史和族谱.
- 通过使用遗传序列数据,调查TULV的起源和迁移途径.
主要方法:
- 用最大概率和贝叶斯推理方法进行了家族遗传学分析和家族地理学重建.
- 从公共数据库中分析了735个TULV S段序列,包括采样时间和地理位置.
- 对TULV病毒替代率的估计.
主要成果:
- 据估计,TULV S部门的替代率为2.26 × 10-3 替代/地点/年.
- 植物地理分析表明,黑海地区是TULV传播的潜在来源.
- 检测到TULV向欧洲引入的单一血统,随后是局部循环.
结论:
- 黑海地区被确定为TULV传播的可能来源.
- TULV可能通过单一的引入事件传播到欧洲,随后进行了当地多样化.
- 了解TULV的进化历史对于评估其流行病学影响至关重要.
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