抗结核疗法后的皮肤药物反应:尼泊尔的一个病例报告
Himal Bikram Bhattarai1, Jeshika Yadav2, Sangrila Sapkota2
1Gandaki Medical College Teaching Hospital and Research Center, Pokhara, Nepal.
SAGE open medical case reports
|November 13, 2023
概括
严重的皮肤不良药物反应 (SCARs) 可以使结核病治疗复杂化. 这一案例凸显了管理这些反应的重要性,以确保有效的结核病治疗和预防进一步的并发症.
科学领域:
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 皮肤不良药物反应 (CADR) 是抗结核疗法 (ATT) 的常见副作用.
- 严重的CADR可能需要停止治疗,使结核病管理复杂化.
- 及时识别和管理对于防止严重后果至关重要.
研究的目的:
- 在一线抗结核治疗期间出现严重的皮肤不良药物反应.
- 讨论这种反应的管理以及随后使用二线ATT的方法.
- 强调需要明确的指导方针对肺结核患者的CADRs的再挑战疗法.
主要方法:
- 一个49岁的肥胖男性患者的病例报告.
- 皮肤反应的开始和进展的详细描述.
- 管理策略包括停止ATT,支持性护理和启动二线ATT.
主要成果:
- 患者在24小时内出现了泛性黄斑发疹,进展为手掌上的块.
- 停止了抗结核治疗,患者接受了支持性护理.
- 患者在抗胰岛素,全身类固醇,莫西素和贝达基林的治疗下出院.
结论:
- 严重的皮肤不良药物反应在治疗结核病方面带来了重大挑战.
- 有效的管理包括迅速识别,支持性护理和明智地使用二线ATT.
- 制定再挑战治疗指南对于优化结核病治疗结果至关重要.
相关概念视频
Pulmonary Tuberculosis V
183
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
183
Pulmonary Tuberculosis IV
144
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
144
Pulmonary Tuberculosis III
339
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
339
Pulmonary Tuberculosis I
246
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
246
Allergic Drug Reactions
850
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
850
Pulmonary Tuberculosis II
243
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
243


