过去20年来牛皮病研究的全面概述:基于机器学习的文献识别分析
Chenyang Yu1,2, Yingzhao Huang3, Wei Yan1
1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in immunology
|November 13, 2023
概括
这份图书统计分析揭示了牛皮研究的关键趋势,强调分子病变和皮肤炎症作为主要热点. 还注意到对指甲牛皮和相关并发症的注意力增加.
科学领域:
- 皮肤病学 皮肤病学
- 图书统计学 图书统计学
- 计算生物学 计算生物学
背景情况:
- 越来越多的牛皮研究带来了信息管理的挑战.
- 由于缺乏元数据处理工具,缺乏全面的文献计量分析.
研究的目的:
- 评估研究趋势,并通过使用文献计量和机器学习分析识别牛皮的当前热点.
- 提供关于牛皮研究演变的宏观视角.
主要方法:
- 从PubMed中使用MeSH术语"牛皮"提取了28178篇出版物 (2003-2022年).
- 应用隐性迪里克莱特分配 (LDA) 给摘要,用于主题识别和趋势分析.
- 利用卢温算法绘制主题关系并识别研究集群.
主要成果:
- 确定了最大的贡献国 (美国,中国,意大利) 和频繁的MeSH术语 ("疾病严重性指数"",治疗结果"",皮肤病原体").
- LDA揭示了关键的研究领域:"分子致病","临床试验"和"皮肤炎症".
- 突出突出出现的热点,如"指甲牛皮"",流行病学研究"和并发症 ("心血管并发症"",牛皮关节炎"",肥胖"",心理障碍").
结论:
- 牛皮的研究正在迅速推进,目前的焦点是"分子发病","皮肤炎症"和"临床试验".
- "皮肤炎症"和"生物病原体"之间的联系表明,基础研究有效地转化为临床研究.
- 对"指甲牛皮","流行病学研究"和并发症的兴趣日益增长,表明研究范围正在扩大.
相关概念视频
Protein-protein Interfaces
12.5K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.5K
Genome-wide Association Studies-GWAS
13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.5K
Protein Networks
4.0K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.0K


