在患有2型肌肉性缩症的患者中,干部肌肉功能障碍及其对慢性腰部疼痛的贡献
Daniela Vlazna1,2,3, Peter Krkoska1,2, Michaela Sladeckova1,2,3,4
1Department of Neurology, Center for Neuromuscular Diseases (Associated National Center in the European Reference Network ERN EURO-NMD), University Hospital Brno, Brno, Czechia.
Frontiers in neurology
|November 13, 2023
概括
肌性缩症2型 (MD2) 患者经常经历干肌功能障碍和慢性腰部疼痛 (CLBP). 腰部延伸器强度降低是MD2中CLBP的重要危险因素.
科学领域:
- 神经学 神经学
- 肌肉骨系统疾病 肌肉骨系统疾病
- 康复医学 康复医学 康复医学
背景情况:
- 肌性缩症2型 (MD2) 的特征是肌肉逐渐疲软,经常影响轴心肌肉.
- 慢性腰部疼痛 (CLBP) 是患有MD2的个体常见的抱怨.
- 干部肌肉功能障碍,包括呼吸肌肉,可能导致MD2患者出现的症状.
研究的目的:
- 评估MD2患者的干部和呼吸道肌肉功能.
- 为了确定在MD2中CLBP的流行率.
- 为了确定MD2中CLBP的风险因素,特别是干部肌肉功能障碍.
主要方法:
- 40名MD2患者接受了全面的干肌功能测试,包括力量和耐力评估.
- 呼吸道肌肉的强度被量化测量.
- 神经学评估包括肌肉衰弱,肌,疼痛评估,以及关于残疾和体力活动的验证问卷.
主要成果:
- MD2患者表现出显著的干部和呼吸肌肉功能障碍,强度和耐力降低.
- 在MD2队列中,CLBP的患病率为52.5%.
- 最大同度腰部伸展器强度≤15.8公斤是CLBP (OR=37.3) 的唯一独立显著风险因素,同时还注意到肌痛严重程度和体力活动减少.
结论:
- MD2与轴性肌肉功能障碍,呼吸道肌肉衰弱和高频率的CLBP有关.
- 腰部延伸器强度受损是MD2患者中CLBP的关键风险因素.
- 这些发现可以为MD2的管理和预防策略提供信息.
相关概念视频
Muscles of the Vertebral Column
1.4K
The back muscles that lie deep into the thoracolumbar fascia are called intrinsic or true back muscles. These muscles are divided into four layers: superficial, intermediate, deep, and deepest layers.
Superficial Layer:
The superficial layer consists primarily of the splenius muscles, which include the splenius capitis and splenius cervicis. These muscles are mainly responsible for the head and cervical spine movements, including extension, rotation, and lateral bending. The splenius capitis...
Superficial Layer:
The superficial layer consists primarily of the splenius muscles, which include the splenius capitis and splenius cervicis. These muscles are mainly responsible for the head and cervical spine movements, including extension, rotation, and lateral bending. The splenius capitis...
1.4K
Disorders of the Skeletal Muscle
966
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
966
Axial and Appendicular Muscles
1.4K
Skeletal muscles, the key players in our body's movement, can be classified into two groups based on their location and function: axial muscles and appendicular muscles. These classifications reflect the primary roles the muscles play in the body's structure and movement.
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and...
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and...
1.4K
Satellite Stem Cells and Muscular Dystrophy
2.0K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
2.0K
Skeletal Muscle Relaxants: Therapeutic Uses
492
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
492
Relaxation of Skeletal Muscles
3.3K
The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
3.3K


