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益生素抑制剂改变的产生,丸形态和相关基因表达在喀什米尔山羊

Meijing Chen¹, Chunhui Duan¹, Xuejiao Yin¹

¹College of Animal Science and Technology, Hebei Agricultural University, Baoding, China.

Frontiers in veterinary science

|November 13, 2023

概括

在喀什米尔山羊中,勃罗莫克里丁治疗抑制了前性蛋白,增加了丸激素和黄素化激素. 这表明,益乳素负面调节丸功能和精子生成.

科学领域:

生殖生物学生殖生物学
内分泌学在内分泌学.
动物科学动物科学

背景情况:

益生素 (PRL) 是一种具有多种生理作用的激素,包括对生殖的影响.
它在男性性腺功能中的特殊作用,特别是在喀什米尔山羊中,需要进一步阐明.

研究的目的:

调查益生菌对喀什米尔山羊丸功能的影响.
为了确定基底是什么分子机制,以调节精子生成和的生产.

主要方法:

喀什米尔山羊接受了布罗莫克里普丁 (一种益生素抑制剂) 或对照药的30天治疗.
分析了血清激素水平 (益生素,,LH,FSH) 和丸的参数.
用RNA测序和qRT-PCR来识别差异表达的基因和途径.

主要成果:

勃罗莫克里丁治疗显著降低了前素水平,同时增加了丸激素和化激素 (LH).
丸分析显示,在治疗组中,生殖管直径和精子生长表皮质厚度增加.
RNA测序确定了142个差异表达的基因,主要涉及到细胞外基因组,河马信号和类固醇激素生物合成.

结论:

益生菌似乎对喀什米尔山羊的丸功能和精子生成产生负面调节.
抑制前乳素可以增强的产生和精子的发育,可能是通过类固醇激素生物合成途径.
这项研究提供了关于喀什米尔山羊男性生殖健康的荷尔蒙调节的见解.

关键词:

在RNA-Seqq.它们是mRNARNA.益生菌蛋白是一种益生菌素.类固醇激素的生物合成测试测试测试测试

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