评估喘严重程度与血清维生素D水平之间的关系:一个横截面研究
Navjot Kaur1, Vipul Kumar1, Jagjot Singh1
1Department of Pediatrics, Government Medical College, Amritsar, Amritsar, IND.
Cureus
|November 13, 2023
概括
维生素D3缺乏症在患有喘的儿童中很常见,较低水平与较差的喘控制和更多的恶化有关. 这突显了维生素D3与儿童喘管理之间的潜在联系.
科学领域:
- 儿科肺病学 儿科肺病学
- 营养生物化学 营养生物化学
- 临床免疫学临床免疫学
背景情况:
- 维生素D3对于骨健康至关重要,并且越来越多地研究了肌肉皮肤健康之外的作用.
- 维生素D缺乏是一个全球性的健康问题,特别是在儿童群体中.
- 新出现的证据表明,维生素D状态与呼吸系统健康,包括喘之间的潜在联系.
研究的目的:
- 评估患有喘的儿童中维生素D3缺乏症的发生率.
- 为了比较喘儿童和健康对照者的维生素D3水平.
- 研究维生素D3水平与喘控制,严重程度和恶化之间的相关性.
主要方法:
- 一项涉及50名喘儿童 (5-15岁) 和50名年龄相匹配的健康对照在印度旁遮普州进行的横截面研究.
- 对所有参与者进行了人口统计细节和临床检查.
- 测量和比较血清25-OH) 维生素D水平,并分析其与喘控制和严重程度的关系.
主要成果:
- 与健康对照组 (32.08 ± 12.22 ng/ml) 相比,喘儿童的血清维生素D3水平显著降低 (24.62 ± 14.95 ng/ml).
- 患有非控制性喘的儿童的维生素D3水平明显较低 (12.06 ± 4.68 ng/ml),比患有控制性喘 (44.82 ± 10.48 ng/ml) 的儿童要低得多.
- 观察到较低的维生素D3水平与喘严重程度增加,控制较差,急性恶化较多之间存在显著的相关性.
结论:
- 低血清维生素D3水平在患有喘的儿童中比健康儿童更为普遍.
- 维生素D3水平与儿童患者的喘控制,严重程度和急性恶化频率有显著的关联.
- 这些发现表明,维生素D3补充剂在儿童喘管理中可能发挥作用.
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