乳腺癌患者心血管自主功能障碍的概况 乳腺癌患者
Ekta Khandelwal1, Sumeet Tripathi2, Ashutosh Gupta3
1Department of Physiology, All India Institute of Medical Sciences, Raipur, Raipur, IND.
Cureus
|November 13, 2023
概括
乳腺癌化疗患者表现出显著的心脏自主功能障碍 (CAD),以减少心率变化 (HRV) 表示. 这种自主功能障碍影响患者的生活质量和生存,需要监测.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 生理学 生理学 生理学
背景情况:
- 自主功能障碍,特别是心脏自主功能障碍 (CAD),在接受化疗的乳腺癌患者中很普遍.
- 慢性肺炎显著影响患者的发病率,死亡率和生活质量,并与降低的生存率有关.
- 监测心血管自主功能对于管理疾病预后和化疗相关副作用至关重要.
研究的目的:
- 在接受化疗的乳腺癌患者中评估心脏自主功能.
- 为了评估基线心率变化 (HRV) 和自主反应能力,使用Ewing的测试电池.
- 在这个患者群体中调查CAD的患病率和程度.
主要方法:
- 一项病例对照研究,将25名乳腺癌患者 (I-III阶段,30-65岁,3次化疗周期) 与25名健康女性对照进行比较.
- 心率变化 (HRV) 通过领先II心电图 (ECG) 记录.
- 在专门的自主功能实验室中进行的自主反应性测试.
主要成果:
- 与对照组相比,接受化疗的乳腺癌患者的时间域和频率域HRV参数明显较低.
- 在患者组中观察到自主反应能力的显著损失.
- 交感和副交感功能在患者和健康个体之间显示出显著的损伤.
结论:
- 化疗或癌症本身可能导致乳腺癌患者观察到的自主功能显著丧失.
- 自主功能障碍在癌症患者中非常普遍,并与各种症状相关.
- 由于其临床影响,对癌症人群中自主功能障碍的进一步研究至关重要.
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