这是达拉图穆马布诱导的第一个发性肝衰竭病例
Ali Tariq Alvi1,2, Sachin George Mathew1, Murali Shankar3
1Internal Medicine, HCA Florida Westside Hospital, Plantation, USA.
Cureus
|November 13, 2023
概括
本案例报告详细介绍了第一例致死性药物诱导肝衰竭的病例,该病例是由化学疗法剂达拉图马布引起的. 该患者在治疗多发性骨髓瘤后不久就出现了发性肝衰竭.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 药物诱导性肝衰竭 (DILF) 是急性肝损伤的重要原因之一.
- 达拉图姆是FDA批准的化疗剂,通常用于多发性骨髓瘤.
- 从达拉图穆马布的DILF的潜力以前没有记录.
研究的目的:
- 报告第一个可能由达拉图穆马布诱导的 fulminant 肝衰竭 (FHF) 病例.
- 强调在接受化疗的患者中考虑罕见药物毒性的重要性.
主要方法:
- 一个77岁的男性患有多发性骨髓瘤的病例报告.
- 详细的临床表现,治疗过程和达拉图穆马布输注后的结果.
主要成果:
- 患者在第一次静脉注射达拉图穆马布输液两周后出现了FHF.
- 尽管接受了N-乙半氨酸治疗,但肝功能逐渐下降.
- 患者最终因肝功能衰竭而死亡.
结论:
- 达拉图穆马布应该被认为是药物诱导的肝衰竭的潜在原因.
- 早期识别和管理DILF至关重要,尽管结果可能很差.
- 需要进一步研究达拉图穆马布的肝毒性.
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