在慢性阻塞性肺部疾病 (COPD) 患者中,萨科佩尼亚和慢性功能衰竭 (公开和隐蔽) 之间的关联:一个横截面研究
Yogesh M1, Anjali K Dave1, Shubham S Patel1
1Community Medicine, Shri M. P. Shah Government Medical College, Jamnagar, IND.
Cureus
|November 13, 2023
概括
肌肉质量下降的萨尔科佩尼亚在COPD患者中非常普遍,并且与慢性脏疾病有显著的关联. 早期检测COPD患者的和脏问题对于更好的健康结果至关重要.
科学领域:
- 老年学是指老年学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肺部病理学 肺部病理学
背景情况:
- 标志着肌肉质量,力量和功能的损失的萨尔科佩尼亚在COPD等慢性疾病中很常见.
- 慢性脏病 (CKD) 影响了大量的肉骨患者.
- 之前的研究表明,15-55%的稳定性COPD患者患有肉症.
研究的目的:
- 为了研究COPD患者的肉类和慢性功能衰竭 (CRF) 之间的关联.
- 为了确定入院COPD患者中缩症和CRF的患病率.
主要方法:
- 一项涉及住院成人COPD患者的横截面研究.
- 使用亚洲 Sarcopenia 工作组 (AWGS) 标准进行评估,包括手握强度和生物电阻分析.
- 慢性功能衰竭 (CRF) 通过使用MDRD方程计算膜过率 (GFR) 来评估.
- 统计分析包括独立样本t测试,奇平方和多变量逻辑回归.
主要成果:
- 这项研究发现,COPD患者中有52%的人患有肉症.
- 露面和隐蔽的CRF分别在31.5%和27%的患者中存在.
- 麻症患者的FEV1和FEV1/FVC显著降低.
- 随着BODE和mMRC得分的提高,肉症的发病率增加.
- 无论是明显的还是隐藏的CRF都与萨尔科佩尼亚的几率增加了四倍 (AOR=4).
结论:
- 在COPD患者中,肉症的患病率很高.
- 在COPD中,肉类和公开和隐蔽的慢性功能衰竭之间存在显著的关联.
- 早期识别和治疗和CRF对于改善COPD患者的临床结果至关重要.
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