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在术后妄想中进行的B试验:复制研究的复制研究

Marinus Fislage^1,2, Insa Feinkohl^3,4, Friedrich Borchers¹

¹Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Anesthesiology and Operative Intensive Care Medicine (CCM, CVK), Berlin, Germany.

|November 13, 2023

概括

步道测试B (TMT-B) 显示了与老年人手术后妄想风险的相关性. 然而,单独的TMT-B对临床使用具有较低的预测能力.

科学领域:

老年医学老年医学
神经心理学神经心理学
外科手术的结果

背景情况:

步道制作测试B (TMT-B) 评估认知灵活性和相关领域.
关于TMT-B和术后妄想风险的先前研究是有限的和不一致的.
这项研究旨在验证术前TMT-B表现与术后妄想发病率之间的关联.

研究的目的:

为了研究Trail Making Test B (TMT-B) 对老年手术患者手术后痴呆症的预测价值.
为了证实或驳斥以前关于TMT-B与妄想之间的关联的发现.
评估TMT-B作为术后痴呆症独立预测者的临床实用性.

主要方法:

一项双国,双中心的纵向观察队列研究包括841名没有痴呆症的大型手术的老年人 (≥65岁).
采集了手术前的TMT-B得分,每天两次使用验证的工具监测妄想.
使用后勤回归和ROC曲线分析来评估TMT-B的预测性能,并对异常值和缺失数据进行敏感性分析.

主要成果:

151名 (18%) 患者出现了术后狂妄症.
TMT-B评分与妄发病率有显著的相关性 (每10秒的OR增量为1.06;P=0.001).
在ROC曲线下的面积为0.60 (P<0.001),表明预测性能低. 损伤或缺失的TMT-B数据也预测了妄想 (OR 2.74).

结论:

追踪测试B (TMT-B) 在统计学上与术后妄想有关.
然而,作为一个独立的测试,TMT-B的预测性能很低.
目前,TMT-B在临床实践中不适合预测妄想.

关键词:

老年人的麻醉疗法开放科学是一个开放的科学.在外科手术期间的医学.在手术后出现的妄想症.复制复制复制复制复制复制复制风险预测风险预测步道制作试验试验步道制作试验

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