阿根廷的Wichí和Criollos之间的表观遗传衰老差异:从基因组历史和生态学的见解
Vincenzo Iannuzzi1, Stefania Sarno1, Marco Sazzini1,2
1Department of Biological, Geological and Environmental Sciences, Laboratory of Molecular Anthropology & Centre for Genome Biology, University of Bologna, Bologna, Italy.
Evolution, medicine, and public health
|November 13, 2023
概括
与混杂的克里奥洛人相比,原住民维奇人表现出加速表观遗传衰老. 遗传祖先部分解释了这些差异,但生态和生活方式因素显著影响人类衰老中的表观遗传变异.
科学领域:
- 人类衰老研究研究.
- 人口遗传学 人口遗传学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 基于DNA甲基化的表观遗传估计器是人类衰老的关键生物标志物.
- 对土著人口表观遗传变异的研究是有限的.
- 这项研究主要集中在阿根廷的Gran Chaco地区.
研究的目的:
- 调查美洲原住民Wichí和混杂的克里奥洛斯之间的表观遗传估计差异.
- 利用人口遗传方法来了解人类衰老的变化.
- 检查遗传和非遗传因素对表观遗传年龄的影响.
主要方法:
- 使用Infinium MethylationEPIC阵列对24个Wichí和24个Criollos进行了DNA甲基化分析.
- 计算了16个表观遗传估计器来评估表观遗传年龄.
- 使用HumanOmniExpress BeadChip检查了全基因组的遗传变异.
主要成果:
- 与克里奥洛斯相比,美国原住民维奇在五个估计器中表现出明显较大的表观遗传年龄.
- 当地的祖先,而不是全球的祖先,与克里奥洛人的表观遗传年龄加速相关.
- 人口生态和环境因素对观察到的表观遗传差异有所贡献.
结论:
- 基因组历史部分解释了种群之间的表观遗传变异.
- 非遗传因素,包括生活方式和生态,显著影响表观遗传衰老.
- 了解这些因素对于解决人类表观遗传衰老变异性至关重要.
关键词:
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