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较高的纯音值与与听觉处理和注意力分配相关的皮质区域的微观结构变化有关

Linda K McEvoy^1,2, Jaclyn Bergstrom³, Donald J Hagler⁴

¹Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.

Journal of Alzheimer's disease : JAD

|November 13, 2023

概括

听力损失与听觉和额头区域的大脑变化有关,而不是加速的大脑衰老. 这些变化可能会通过影响大脑弹性而导致痴呆风险.

科学领域:

神经科学是一个神经科学.
老年学是指老年学的学科.
审计科学审计科学

背景情况:

听力损失越来越被认为是认知能力下降和阿尔茨海默病的重要危险因素.
连接听力障碍与这些神经疾病的潜在生物机制在很大程度上仍然不清楚.

研究的目的:

为了研究听力障碍和大脑衰老之间的关联.
检查听力损失是否与大脑区域的微观结构变化相关,这些区域对听觉和认知功能至关重要.

主要方法:

利用了来自Rancho Bernardo健康衰老研究的130名参与者的数据,包括听力图和脑MRI.
计算了大脑预测年龄差异 (Brain-PAD) 并分析了皮和前皮层的区域扩散指标.
采用线性回归分析,调整人口统计和健康相关因素.

主要成果:

纯音调平均 (PTA) 听力值与大脑PAD无关,这表明与高级大脑衰老无关.
PTA显著与右半球时和正面区域的限制扩散减少和自由水扩散增加有关.
这些微观结构变化表明,与听觉处理和注意力控制相关的大脑组织完整性的改变.

结论:

听力障碍与加速的大脑衰老无关,但与微观结构性大脑变化有关.
在听觉和额头区域的这些大脑变化可能在听力损失的个体中观察到的痴呆风险增加中发挥作用.
由于听力障碍导致的补偿性大脑变化可能会降低神经弹性,从而增加神经系统疾病的脆弱性.

关键词:

阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.这就是为什么MRI是MRI.痴呆症痴呆症是一种痴呆症.听力损伤听力损伤神经成像是一种神经成像.

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