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核磁共振可以预测嗅觉损失和改善创伤后嗅觉功能障碍吗?
J W Hsieh1, V Lenoir2, R Sipione3
1Rhinology-Olfactory Unit, Department of Otorhinolaryngology - Head and Neck Surgery, Geneva University Hospitals, Geneva, Switzerland; The Inner Ear and Olfaction Lab, Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Rhinology
|November 13, 2023
概括
大脑MRI模式可以对创伤后嗅觉功能障碍 (PTOD) 的严重程度进行分类,并预测嗅觉改善. 较轻微的脑病变与PTOD患者更好的嗅觉恢复相关.
科学领域:
- 神经成像是一种神经成像.
- 嗅觉功能障碍 嗅觉功能障碍
- 创伤性脑损伤是一种创伤性脑损伤.
背景情况:
- 创伤后嗅觉功能障碍 (PTOD) 在头部受伤后很常见.
- 在PTOD中MRI的诊断和预后价值仍然不清楚.
- 目前的理解缺乏对神经退行程度的分类和MRI对嗅觉恢复的预测能力.
研究的目的:
- 使用MRI对PTOD患者的神经退行症的程度进行分类.
- 为了将MRI发现与化学感官功能障碍 (嗅觉,味觉,三角体) 相关联.
- 确定MRI是否可以预测PTOD的嗅觉改善.
主要方法:
- 对56名PTOD患者进行了回顾性队列研究.
- 患者接受了嗅觉,味觉和三胞胎功能以及MRI的心理物理测试.
- 放射科医生评估了40个大脑区域的病变;对46名患者的随访数据可用.
主要成果:
- 确定了四种不同的脑损伤模式,与阿诺斯米亚,低血压和诺莫斯米亚有关.
- 两个群体显示了100%的特异性和阳性预测价值的 anosmia.
- 轻微的病变预测了72.7%的嗅觉改善机会,明显高于较大的病变 (21.7-37.5%).
结论:
- 通过MRI进行大脑损伤分析有助于在PTOD中证实气味测试结果.
- 磁力共振成像结果可以预测主观和可测量的嗅觉改善.
- 这项研究确定了MRI在治疗创伤后嗅觉丧失方面的预后价值.
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