柏柏林和黄素在循环胺诱导的间歇性囊炎中具有泌尿保护作用
Murat Demir1, Fikret Altındağ2
1Department of Urology, Faculty of Medicine, Van Yüzüncü Yıl University, Van, Turkey.
Environmental toxicology
|November 13, 2023
概括
柏柏林 (BER) 和黄素 (CUR) 治疗在大鼠中显著减少了循环胺 (CYP) 诱导的囊炎. 这些天然化合物通过减少炎症和亡来减轻膀损伤.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 自然产品化学 自然产品化学
- 实验病理学实验病理学
背景情况:
- 环胺 (Cyclophosphamide,简称CYP) 是一种已知可诱发囊炎的化疗剂,其特征是膀组织受到显著损伤.
- 研究天然化合物对抗药物诱导毒性的保护作用对于开发辅助疗法至关重要.
研究的目的:
- 在CYP诱导囊炎的实验模型中评估柏柏林 (BER) 和黄素 (CUR) 的治疗潜力.
- 评估BER和CUR对胰腺病理变化,细胞亡和膀炎症标志物的影响.
主要方法:
- 这项研究使用了由CYP诱导的囊炎的老鼠模型,动物随机分配到六个组:对照组,DMSO,CYP,CYP+BER,CYP+CUR和CYP+BER+CUR.
- 使用马森-特里克罗姆染色进行了组织病理学分析,以评估组织损伤和纤维化.
- 免疫组织化学染色评估了亡标志物caspase-3和炎症性细胞因子TNF-α,IL-6和IL-10的表达.
主要成果:
- 服用CYP导致了严重的膀病理,包括,高血压,出血,亡和上皮稀疏.
- BER和CUR治疗显著改善了这些组织病理变化,减少了Mason-Trichrome染色,表明纤维化较少.
- 用BER和CUR治疗降低了caspase-3,TNF-α和IL-6的表达,同时增加了抗炎细胞因子IL-10的表达.
结论:
- 柏柏林和黄素在老鼠模型中显示出对循环胺诱导的囊炎具有显著的保护作用.
- 这些天然化合物可以通过减少亡和炎症来发挥它们的治疗效益,从而改善胰腺病理性膀损伤.
- BER和CUR代表了管理或预防药物诱导囊炎的有希望的药物.
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