肠道中的短链脂肪酸生产者与儿科多发性硬化症发病相关
Vinicius A Schoeps1, Xiaoyuan Zhou1, Mary K Horton2
1Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
Annals of clinical and translational neurology
|November 13, 2023
概括
儿科多发性硬化症 (MS) 与肠道细菌有关. 这项研究发现,某些细菌,特别是短链脂肪酸生产者,可以保护儿童免受MS发病.
科学领域:
- 微生物组研究的研究.
- 神经免疫学 神经免疫学
- 儿科神经学 儿科神经学
背景情况:
- 动物模型表明肠道微生物群在多发性硬化症 (MS) 中的作用,但人类研究得出了不一致的结果.
- 儿科发病的MS提供了一个独特的窗口来研究更接近疾病发病的微生物群,最大限度地减少混因素,如并发症和疾病持续时间.
研究的目的:
- 在儿科发病的MS中研究肠道微生物组的组成和功能.
- 确定儿童MS的微生物关联,并了解潜在的保护机制.
主要方法:
- 一项多中心的病例对照研究将35例儿科多发性硬化症病例与健康对照进行了匹配.
- 利用线性混合效应模型,加权相关联网络分析和PICRUSt2进行微生物和功能丰度预测.
- 通过独立的加拿大-美国病例/对照队列验证的结果.
主要成果:
- 确定了与MS状态相关的显著微生物共发生网络.
- 观察到特定细菌种群的潜在保护作用,包括Ruminococcaceae和Lachnospiraceae.
- 功能预测表明,短链脂肪酸 (SCFA) 生产者在健康对照中的作用.
结论:
- 肠道微生物组的改变,特别是减少的SCFA产生细菌,可能会导致儿科MS的出现.
- 生产SCFA的细菌可能在MS的发展中起着保护作用.
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