肠道微生物群和细胞癌的免疫疗法
Stefano Bibbò1, Serena Porcari1, Livio Enrico Del Vecchio1
1CEMAD Digestive Disease Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Università Cattolica del Sacro Cuore, Roma, Italy.
Human vaccines & immunotherapeutics
|November 13, 2023
概括
肠道微生物组影响癌症治疗. 通过诸如益生菌或便微生物种移植 (FMT) 等方法调节肠道细菌,可以改善患者对癌治疗中的免疫检查点抑制剂 (ICI) 的反应.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 人们越来越认识到肠道微生物组在癌症发展和进展中的作用.
- 微生物组组成显著影响患者对免疫检查点抑制剂 (ICI) 的反应.
研究的目的:
- 本综述探讨了肠道微生物组在改善癌治疗ICI的临床反应中的作用.
- 探索微生物组调制作为瘤学中的治疗策略.
主要方法:
- 对研究肠道微生物组及其对ICI治疗的影响的文献综述.
- 对微生物组调制技术 (如益生菌和便微生物群移植 (FMT)) 的研究进行分析.
主要成果:
- 肠道微生物组的组成是ICI疗效的关键因素.
- 微生物组调节策略,包括益生菌和FMT,在增强抗癌免疫反应方面表现有前途.
- 这些方法有可能在癌中克服对ICI治疗的耐药性.
结论:
- 准肠道微生物组是通过ICI改善癌治疗结果的有希望的途径.
- 对基于微生物组的疗法进行进一步的研究是有必要的,以优化癌症护理.
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