对心力衰竭患者进行生活方式步行干预,减少排气分数:WATCHFUL试验
Tomas Vetrovsky1, Michal Siranec2, Tereza Frybova2
1Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic (T.V., M. Semerad, V.B.).
Circulation
|November 13, 2023
概括
在心力衰竭患者中,生活方式步行干预增加了每天的步伐,但没有改善功能能力. 需要进行进一步的研究,以确定增加的体力活动与心力衰竭的功能结果之间的联系.
科学领域:
- 心脏病学
- 康复医学
- 公共卫生
背景情况:
- 身体活动,特别是步行,对于治疗心力衰竭和减少排气率 (HFrEF) 是至关重要的.
- 对于HFrEF患者来说, 步行融入日常生活是一种实用方法.
- 评估生活方式干预对HFrEF功能能力的影响至关重要.
研究的目的:
- 评估6个月的生活方式步行干预是否改善HFrEF患者的功能能力.
- 与通常护理相比,评估干预对6分钟步行测试 (6MWT) 的影响.
- 探索对次要结果的影响,包括身体活动水平和生物标志物.
主要方法:
- 一个为期6个月的多中心随机对照试验 (WATCHFUL试验) 涉及HFrEF患者 (NYHAII- III类).
- 干预组使用活动追踪器, 每月接受电话咨询以改变行为.
- 对照组接受了通常的治疗;主要结果是6个月后的6MWT距离.
主要成果:
- 在6个月后,两组之间的6MWT距离没有显著差异 (平均差异为7.4米,P=0. 345).
- 干预组的平均每日步数 (+ 1420步) 和中度至强度体力活动 (+ 8. 2分钟) 显著增加.
- 对于其他次要结果,没有观察到组间的差异.
结论:
- 生活方式步行干预成功增加了身体活动,但没有改善HFrEF患者的功能能力.
- 增加步骤和功能改进之间的脱节需要进一步调查.
- 未来的研究应该探索身体活动与HFrEF功能结果之间的联系机制.
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