肥胖和心脏导电阻塞疾病在中国
Peipei Liu1, Yanxiu Wang2, Xiaofu Zhang3
1School of Public Health, North China University of Science and Technology, Caofeidian Eco-city, Tangshan, Hebei, China.
JAMA network open
|November 13, 2023
概括
肥胖与心脏导电阻 (CCB) 的更高风险有关,特别是第一级心房阻塞 (FAVB),高度心房阻塞 (HAVB) 和左前带阻塞 (LAFB). 老年人和糖尿病患者的风险更大.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 高体重指数 (BMI) 与老年人心脏导电阻塞 (CCB) 风险增加有关.
- 有限的研究存在于一般人口的肥胖-CCB关联.
研究的目的:
- 调查肥胖和CCB之间的关联,包括其亚型.
- 分析基于年龄和糖尿病等并发症的风险变化.
主要方法:
- 来自凯卢安研究 (2006-2018) 的86,635名参与者的队列研究.
- 根据BMI定义的肥胖 (正常<24,超重24-<28,肥胖≥28).
- 通过心电图诊断的CCB;使用多变量考克斯回归分析.
主要成果:
- 肥胖 (BMI ≥28) 与CCB风险增加有关 (HR,1.21).
- 肥胖增加了FAVB (HR,1.44),HAVB (HR,1.99) 和LAFB (HR,1.29) 的风险.
- 肥胖导致的CCB风险增加在老年人 (≥65岁) 和糖尿病患者中更高.
结论:
- 肥胖是CCB,特别是FAVB,HAVB和LAFB的独立风险因素.
- 年龄和糖尿病加剧了肥胖-CCB风险关联.
- 研究结果强调了体重管理对心血管健康的重要性.
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