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Updated: Jul 11, 2025

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

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通过准CDK2和EGFR-ERK信号传导,具有协同作用的抗癌作用

Jinhuan Wu1,2, Yuping Chen1,2, Rui Li1,2

  • 1Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai, China.

The Journal of cell biology
|November 13, 2023
PubMed
概括

循环素依赖激酶2 (CDK2) 通过激活USP37来调节ERK通路,USP37稳定ERK1/2,促进癌细胞的增殖. 结合CDK1/2和EGFR抑制剂提供了一个协同作用的抗癌策略.

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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