在临床PET中基于能源的散射估计.
James J Hamill1, Jorge Cabello1, Suleman Surti2
1Siemens Medical Solutions, Knoxville, Tennessee, USA.
Medical physics
|November 13, 2023
概括
基于能量的散射估计 (EBS) 显示了与正电子发射断层扫描 (PET) 定量成像的单散射模拟 (SSS) 相似的结果. 在瘤全身PET/CT扫描中,EBS可以取代SSS,特别是当SSS遇到技术问题时.
科学领域:
- 医疗成像医学成像
- 核医学就是核医学.
- 射线物理学 射线物理学
背景情况:
- 精确的散射校正 (SC) 对于定量正子发射断层扫描 (PET) 成像至关重要.
- 单散射模拟 (SSS) 是目前的SC标准,但在PET/CT中患者运动可能会失败.
- 需要使用替代的SC方法来解决SSS的局限性.
研究的目的:
- 详细说明,测试和比较基于能源的散射估计 (EBS) 方法与SSS.
- 为了评估PET/CT成像的幻影和患者研究中的EBS性能.
主要方法:
- 开发了EBS用于Biograph Vision-600 PET/CT扫描仪上的列表模式数据.
- 使用数字化2D能量直方图和代期望最大化方法.
- 使用NEMA NU2-2018,板块,NU 2-1994,心脏和干幻影以及七名肺癌患者的FDG PET扫描进行验证.
主要成果:
- EBS和SSS在视觉上产生了相似的图像,EBS在干幻影中显示出更好的统一性.
- 欧洲证券交易所 (EBS) 显示了2%的分散余值,而SSS则为3%,背景变化略高.
- 幻影研究显示了可比的对比度恢复 (98.2%的EBS与99.6%的SSS),患者病变SUV值在EBS和SSS之间有很强的相关性 (R2=0.9973).
结论:
- 在焦点病变中,EBS提供了与标准化摄入值 (SUV) 的SSS可比的临床相关结果.
- 在幻影中,EBS在某些散射指标上提供了轻微的改进,尽管图像可变性有轻微的退化.
- 对于瘤全身PET/CT,EBS是一种可行的SSS替代品,特别是在SSS失败的情况下.
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