MiniMed 780G先进的混合闭环系统研究,针对1型糖尿病孕妇进行
Clara Guibert1, Lamia Amoura2, Luc Rakotoarisoa2,3
1Obstetrics and Gynecology Department, Diabetes, and Nutrition Department, University Hospital of Strasbourg, Strasbourg, France.
Diabetes technology & therapeutics
|November 13, 2023
概括
MiniMedTM 780G先进的混合闭环系统改善了1型糖尿病孕妇的葡萄糖控制. 然而,孕产妇和新生儿并发症仍然很高,目标仅在一夜之间实现.
科学领域:
- 内分泌学 在内分泌学.
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 医疗器械 医疗器械
背景情况:
- 怀孕期间的1型糖尿病 (T1D) 对母亲和新生儿都有重大风险.
- 先进的混合闭环 (AHCL) 系统在怀孕期间提供了改善血糖管理的潜力.
- 优化血糖控制对于减少T1D怀孕中产妇新生儿并发症至关重要.
研究的目的:
- 评估MiniMedTM 780G AHCL系统对T1D孕妇葡萄糖概况的影响.
- 评估与怀孕期间使用AHCL系统相关的母婴并发症.
- 为了确定AHCL系统的使用是否满足整个怀孕期间推的血糖目标.
主要方法:
- 使用MiniMedTM 780G AHCL系统对患有T1D的孕妇进行观察性,多中心,回顾性研究.
- 持续血糖监测 (CGM) 参数的每月分析,包括范围内的时间 (TIR) 和范围以下的时间 (TBR).
- 关于母亲和新生儿并发症,出生体重和分娩方式的文件.
主要成果:
- 时间在范围 (TIR) 从怀孕早期的46%显著增加到第三季度的66% (P<0.001).
- 夜间TIR始终超过70%,但怀孕期间低于范围的时间增加.
- 孕产妇的并发症包括先兆子 (5/13),新生儿的并发症包括宏观症 (5/14) 和低血糖症 (2/14).
结论:
- MiniMedTM 780G AHCL系统在怀孕期间显示出改善的血糖控制,目标在一夜之间实现.
- 尽管血糖水平有所改善,但孕产妇和新生儿并发症率仍然很高.
- 需要进一步的研究来优化AHCL系统的性能,并减少T1D怀孕中的并发症.
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