RMBase v3.0:解码RNA修改的场景,机制和功能
Jiajia Xuan1,2, Lifan Chen1, Zhirong Chen1
1MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China.
Nucleic acids research
|November 13, 2023
概括
RMBase v3.0 是研究RNA修饰的综合平台,提供工具来探索它们的景观,生物发生和跨物种的功能. 它绘制了73种RNA修饰的地图,并有助于理解它们在各种生物过程和疾病中的作用.
科学领域:
- * 分子生物学 * 分子生物学
- * 生物信息学是一门学科.
- * 基因组学 是一个学科.
背景情况:
- *已知有170多种化学RNA修饰,但它们的流行,机制和功能在很大程度上未被描述.
- *对多种RNA修饰特征的综合分析对于理解表体转录学至关重要.
- * 现有的资源缺乏全面的工具来探索RNA修饰数据.
研究的目的:
- * 开发RMBase v3.0,一个集成的平台,有八个模块用于分析RNA修饰.
- * 提供一个全面的资源来探索转录组范围的景观,生物发生,互动组和RNA修饰的功能.
- *促进研究RNA修饰模式,机制及其与其他生物因素的关系.
主要方法:
- * RMBase v3.0 的开发,这是一个基于网络的平台,有八个专门的模块.
- *使用新型生物信息学管道挖掘数千个表表转录组数据集.
- *整合了关于RNA修饰,基因,酶,基因素修饰,RNA修饰蛋白 (RMPs),RBPs,miRNAs和SNPs的数据.
主要成果:
- * RMBase v3.0映射了62个物种的73个RNA修饰,详细说明了它们在转录组范围内的分布.
- *该平台阐明了23,382个修改站点的生物发生机制,并探索了与基因组修改的相关性.
- *它研究了18种癌症类型中的146个RMP的差异表达,并整合了与各种分子因素的相互作用关系.
结论:
- * RMBase v3.0 作为一个有价值的,全面的资源,用于表表谱学社区.
- * 该平台提供各种工具和集成数据,以深入研究RNA修饰.
- *RMBase v3.0促进了对RNA修饰在基因调节和疾病中的作用的研究.
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