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孕产妇睡眠呼吸障碍和后代生长结果:系统性审查和元分析
Laura Sanapo1, Sandra Hackethal2, Margaret H Bublitz3
1Women's Medicine Collaborative, The Miriam Hospital, Providence, RI, USA; Department of Medicine, Warren Alpert School of Medicine at Brown University, Providence, RI, USA.
Sleep medicine reviews
|November 13, 2023
概括
孕妇在怀孕期间的睡眠呼吸障碍与胎儿生长的改变有关. 像阻塞性睡眠呼吸暂停这样的特定条件,客观地诊断,增加了对孕期新生儿大大的风险.
科学领域:
- 产科和妇科 产科和妇科
- 睡眠医学 睡眠医学
- 新生儿健康 新生儿健康
背景情况:
- 睡眠呼吸障碍 (SDB) 在怀孕期间很普遍,可能会导致母亲的并发症.
- 动物研究表明,SDB间歇性缺氧会影响胎儿发育.
- 关于SDB和后代生长的人类数据仍然存在矛盾.
研究的目的:
- 系统地审查和元分析母亲睡眠障碍呼吸和后代生长之间的关联.
- 澄清不同类型的SDB和诊断方法对胎儿生长结果的影响.
主要方法:
- 63个手稿的系统审查和元分析.
- 包括67,671名孕妇.
- 基于SDB的主观,客观或国际代码定义的研究的分类.
主要成果:
- 习惯性打 (主观) 和阻塞性睡眠呼吸暂停 (客观) 与孕期婴儿大体的风险增加相关.
- 阻塞性睡眠呼吸暂停 (国际代码) 与怀孕年龄小的新生儿的风险增加有关.
- 结果突出了基于SDB类型和诊断方法的差异.
结论:
- 母亲的SDB显著影响后代的生长模式.
- 具体的SDB疾病和诊断方法是关键因素.
- 需要进一步研究妊娠中SDB的潜在机制和治疗干预措施.
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