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基于氧化应激的阿尔茨海默氏病的多功能药物:通过多元组件反应合成的多替代型pyrazine衍生物

Wenxiu Wei1, Lanlan Jing1, Ye Tian2

  • 1Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, PR China.

Bioorganic & medicinal chemistry
|November 13, 2023
PubMed
概括

研究人员开发了新的多功能pyrazine衍生物作为潜在的阿尔茨海默病 (AD) 治疗方法. 化合物A3B3C1显示出有前途的抗氧化剂和多目标活性,包括Nrf2/ARE通路调节.

关键词:
阿尔茨海默氏症是阿尔茨海默氏症的一种疾病.抗氧化剂是一种抗氧化剂.金属离子化金属离子化多元组件反应是多元组件反应.多功能代理多功能代理

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