探索HD-tDCS对μ-阿片类受体的影响和关节障碍的疼痛敏感性:试点随机临床试验研究
Dajung J Kim1, Thiago D Nascimento1, Manyoel Lim2
1Headache and Orofacial Pain Effort (H.O.P.E.) Laboratory, Department of Biologic and Materials Sciences & Prosthodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan; Michigan Neuroscience Institute, University of Michigan, Ann Arbor, Michigan.
The journal of pain
|November 13, 2023
概括
这项研究发现,关节障碍 (TMD) 患者的较高疼痛敏感性与较低的μ-阿片类受体 (μOR) 可用性相关. 高清透直流刺激 (HD-tDCS) 增加了μOR可用性,降低了疼痛敏感性.
科学领域:
- 神经科学是一个神经科学.
- 疼痛研究 疼痛研究
- 医疗成像医学成像
背景情况:
- 部疾病 (TMD) 涉及复杂的疼痛机制.
- μ-阿片类受体 (μOR) 在疼痛调节中起着至关重要的作用.
- 了解TMD中的μOR可用性对于开发有效治疗至关重要.
研究的目的:
- 调查TMD患者疼痛敏感性和μOR可用性之间的关联.
- 评估高清超直流刺激 (HD-tDCS) 对TMD患者疼痛和μOR可用性的影响.
- 探索调节μOR可用性用于TMD疼痛管理的治疗潜力.
主要方法:
- 使用[11C]卡芬坦尼尔的正子发射断层扫描 (PET) 扫描用于测量μOR可用性.
- 患者在主动运动皮层 (M1) 上进行主动或假 HD-tDCS 的每日 10 个会议之前和之后接受了 PET 扫描.
- 实验诱导的疼痛敏感性被评估使用高压盐水输液挑战.
主要成果:
- 右桃体中较低的μOR可用性与TMD患者疼痛敏感度增加有关.
- 活跃的M1 HD-tDCS,与假的相比,增强了马体,杏仁体,海马体和副海马体环中的μOR可用性.
- 治疗后在边缘结构中增加了μOR可用性,与疼痛敏感性降低相关.
结论:
- μ-阿片类受体系统与TMD的疼痛调节有关.
- 超过M1的HD-tDCS通过增加μOR可用性和降低疼痛敏感性来显示TMD的治疗潜力.
- 需要进行更大规模的临床试验,以确认这些发现对TMD疼痛管理的临床意义.
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