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HIF在鱼类炎症中的作用

Xiaowei Shi¹, Feng Gao², Xianliang Zhao²

¹Engineering Lab of Henan Province for Aquatic Animal Disease Control, College of Fisheries, Henan Normal University, Henan Province, PR China; Sanquan Medical College, Henan Province, PR China.

Fish & shellfish immunology

|November 13, 2023

概括

低氧诱导因子 (HIF) 调节鱼类的免疫反应,影响炎症和代谢重编程. 了解 HIF 的理解

科学领域:

分子生物学分子生物学
免疫学免疫学免疫学
鱼类生物学鱼类生物学

背景情况:

在鱼类疾病中经常出现的炎症经常伴随着缺氧.
低氧诱导因子 (HIF) 介导的低氧信号通路对于免疫反应和炎症期间的代谢重编程至关重要.
在调节鱼类炎症反应方面,HIF的分子机制尚不清楚.

研究的目的:

审查HIF在鱼类先天免疫细胞中的特征和作用.
讨论HIF在炎症期间在先天性免疫细胞中对代谢重编程的调节.
为鱼类疾病治疗策略提供针对HIF的见解.

主要方法:

关于鱼类免疫中HIF特征和功能的文献综述.
在细菌和病毒感染期间对HIF在先天免疫细胞中的作用的分析.
讨论HIF对免疫细胞代谢重编程的影响.

主要成果:

在鱼类中,HIF在细胞氧传感和免疫调节中起着至关重要的作用.
在炎症期间,HIF会影响先天免疫细胞表型,功能和代谢适应.
目前对鱼类炎症反应中HIF的特定分子机制的了解有限.

结论:

HIF是鱼类炎症和免疫反应的关键调节者.
需要对HIF分子机制进行进一步的研究,以开发针对鱼类疾病的有针对性的治疗策略.
这一综述作为未来关于HIF在鱼类免疫学和疾病方面的研究的参考.

关键词:

鱼类鱼类鱼类鱼类鱼类氧气过低是因为缺氧.导致缺氧的诱导因子炎症炎症是一种炎症.天生的免疫细胞是天生的免疫细胞.代谢重编程是一种代谢重编程.

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