一个全方位的粉末装载的交联托桑微针贴片,用于高剂量可控药物输送
Ye He1, Mingming Zang1, Jinting Zhang1
1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
International journal of biological macromolecules
|November 13, 2023
概括
这项研究开发了一种用于控制药物输送的新型色素微针贴片. 该贴片提供可调节的药物释放和改善的稳定性,显示出临床应用的希望.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 聚合物化学 聚合物化学
背景情况:
- 传统的药物输送方法面临着药物载荷能力,降解和受控释放的挑战.
- 微针技术为通过皮肤递送药物提供了潜力,但在制备和应用方面仍然存在挑战.
- 基于酸盐的材料由于其生物相容性和生物降解性,对生物医学应用具有吸引力.
研究的目的:
- 为了构建和描述一种新型的粉末载核心外交联托桑微针补丁.
- 评估药物载荷能力,释放动力学和微针贴片的稳定性.
- 评估微针贴片在体内有效性和可控性,用于药物输送,特别是胰岛素.
主要方法:
- 制造带有药物粉末的核心外交叉连接的奇多微针.
- 在体外药物释放研究以评估在不同交叉链密度下释放动力学.
- 在体内低血糖疗效测试中,在使用胰岛素载荷贴片的链毒素诱导的糖尿病小鼠中进行了低血糖疗效测试.
- 在加快储存条件下对胰岛素补丁的稳定性评估.
主要成果:
- 装有粉末的微针贴片显示了高药载荷能力,并将药物的降解降到最低.
- 通过调整微针外的交叉连接密度,成功调整了药物释放概况 (快速或持续).
- 在体内研究证实,通过改变交叉链密度,可以定制胰岛素释放的开始和持续时间.
- 带有不同交叉密度的补丁组合实现了快速降低血糖,持续高达36小时的正常血糖.
- 装在贴片中的胰岛素在40°C保存6个月时表现出良好的稳定性.
结论:
- 开发的含有粉末的奇托桑微针贴片为高剂量,可控的多种药物的输送提供了一个多功能平台.
- 可调节的交叉链密度提供了一种机制,用于精确控制各种治疗需求的药物释放动力学.
- 微针贴片在治疗糖尿病等慢性疾病方面具有显著的潜力,可以改善患者的服从性和治疗结果.
- 这项技术解决了聚合物微针制备和应用的关键挑战,为临床翻译铺平了道路.
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