在左心室辅助器件 (DOAC LVAD) 研究中直接口服抗凝剂阿皮克萨班的设计和推理
Matthew Dimond1, Mary Looby1, Bhruga Shah1
1From the Advanced Heart Failure, Inova Schar Heart and Vascular, Falls Church, VA.
Journal of cardiac failure
|November 13, 2023
概括
这项研究评估了直接口服抗凝剂阿皮克萨班,用于使用左心室辅助器件 (LVAD) 的患者. 它评估了与华法林相比的安全性和可行性,旨在减少晚期心力衰竭中血栓塞栓事件和出血风险.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 药理学 药理学是指药理学的学科.
背景情况:
- 左心室辅助器械 (LVAD) 治疗改善了晚期心力衰竭的结果.
- 患有LVAD的患者需要抗凝药,但面临出血风险.
- 在LVAD患者中,阿皮克萨班的安全性尚未得到充分证实.
研究的目的:
- 在LVAD患者中评估阿皮克萨班与华法林的血液兼容性和安全性.
- 为了确定直接口服抗凝剂治疗在这个人群中的可行性.
主要方法:
- 第二阶段,开放标签,随机化试验 (DOAC LVAD).
- 40名患者随机分配给阿皮克萨班 (5毫克每天两次) 或华法林 (INR目标2.0-2.5).
- 所有患者都接受了阿司匹林 (81毫克/天);对患者进行了24周的随访.
主要成果:
- 主要结局:免于死亡或与血液相容性相关的不良事件 (中风,器械血栓,出血等). ) 的情况.
- 研究的目的是确定可行性,而不是最终的疗效.
结论:
- DOAC LVAD试验将提供关于阿皮克萨班在LVAD患者的使用的关键数据.
- 这些发现可能会为未来的晚期心力衰竭抗凝策略提供信息.
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