甲基化RNAm6通过PTX3依赖的巨细胞平衡来调节过敏性喘中的呼吸道炎症

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Xiao Han1,2, Lijuan Liu3, Saihua Huang4,5

  • 1Institute of Pediatrics, Children's Hospital of Fudan University, National Children's Medical Center, and the Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. sqhx12@126.com.

Nature communications
|November 13, 2023
PubMed
概括

这项研究表明,低水平的METTL3,一种对N6 - 甲基氨酸 (m6A) 修饰至关重要的酶,通过促进M2巨细胞激活来加剧过敏性喘. 这一发现为过敏性气道炎症提供了新的治疗点.

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