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/二次替代酸的物理化学特性和模拟,具有增强的生物相容性和抗菌能力

Ihsan Ullah^1,2,3, Sajjad Ali⁴, Zahoor Ahmad⁵

¹Joint Research Centre on Medicine, The Affiliated Xiangshan Hospital of Wenzhou Medical University (Xiangshan First People's Hospital Medical and Health Group), Ningbo, Zhejiang 315700, P. R. China.

ACS applied bio materials

|November 13, 2023

概括

和配合的酸 (HA) 显示出对骨修复的前景. 这种生物材料消除细菌并刺激骨再生,为硬组织支架提供了双重好处.

科学领域:

生物材料科学生物材料科学
材料化学材料化学
生物医学工程生物医学工程

背景情况:

在酸 (HA) 中的离子替代激活其表面进行骨修复.
(Mg) 和 (Zn) 是增强HA特性的主要补充剂.

研究的目的:

用水热方法制备和描述Mg,Zn和Mg/Zn编码的HA.
研究Mg和Zn代对HA结构,生物相容性和抗菌性能的影响.

主要方法:

,和/编码HA的热水合成.
实验性特征和第一原则计算.
使用MC3T3细胞进行体外生物相容性测试.
对大肠杆菌和金黄色葡萄球菌的抗菌分析.

主要成果:

和离子成功地被纳入HA结构,改变了细胞参数,结晶性和粒子大小.
在10%Mg和10%Zn的Codoping中,导致完全转变为白石阶段.
5%Mg和5%Zn配合HA促进了MC3T3细胞的增殖和分化.
5%Zn-doped和codoped的HA表现出显著的抗菌特性.
代用HA (5%Mg和5%Zn) 显示出抗菌活性和骨再生潜力.

结论:

与5%Mg和5%Zn共同替代的HA是硬组织支架的一个有希望的生物材料.
这种材料有效地消灭细菌并诱导骨再生,提供双重治疗方法.

关键词:

它是一种抗菌药物,具有抗菌作用.生物相容性生物相容性氧帕提特是一种氧帕提特.的含量是多少? 的含量是多少?建模建模模型建模模型 ,和的使用情况.

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