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Updated: Jul 11, 2025

High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
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一个CRISPR药物扰动地图,用于识别与常用的化疗药物结合的化合物

Hyeong-Min Lee1, William C Wright1, Min Pan1

  • 1Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.

Nature communications
|November 13, 2023
PubMed
概括

发现有效的癌症药物组合是具有挑战性的. 这项研究使用CRISPR屏幕来映射使癌细胞对化疗敏感的基因,确定神经母细胞瘤和其他癌症的改进组合疗法.

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